359. Shelar S. B., Narasimhan M., Shanmugam G., et al. Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle. FASEB Journal. 2016;30(5):1865–1879. doi: 10.1096/fj.201500153. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
High-density lipoprotein (HDL – the "good" cholesterol) ordinarily transports excess cholesterol from the tissues back to the liver. In the liver, the cholesterol is either recycled for future use or excreted into bile. HDL's reverse transport is the only way that cells can get rid of excess cholesterol. It helps protect the arteries and, if there is enough HDL present, it can even reverse the build up of fatty plaques in the arteries. When there are excessive amounts of VLDL and triglyceride present, however, HDL concentrations in the blood decrease.
Just made this and as a normal bread lover, I am very impressed! But do have a question. Can you over cook this? Mine seems a bit light inside, like a teenie bit mooshy, and can’t see it holding up in a sandwich. The temp was at 200 inside but I had already had it in for like 50 minutes longer than the posted time and I could still hear a little squish but didn’t want to over cook.
Although the hunger-reducing effect of KD is well-documented, its main mechanisms of action are still elusive. The global picture is complicated by the contradictory role of ketosis on anorexigenic and orexigenic signals (summarized in Figure Figure4).4). Ketones (mainly BHB) can act both orexigenically or anorexigenically. In the orexigenic mechanism, it increases the circulating level of adiponectin, increasing brain GABA and AMPK phosphorylation and decreasing brain ROS production. The anorexigenic mechanism triggers a main normal glucose meal response, increasing circulating post-meal FFA (thus reducing cerebral NPY), maintaining CCK meal response and decreasing circulating ghrelin. It can be postulated that the net balance of the contrasting stimuli results in a general reduction of perceived hunger and food intake. More studies are needed to explore the mechanism of potential beneficial effects of KD on food control.
What causes high cholesterol? High cholesterol is a risk factor for heart attacks and coronary heart disease, because it builds up in the arteries, narrowing them. It does not usually have any symptoms, and many people do not know they have it. We look at healthy levels and ranges of cholesterol, at ways to prevent it, and medications to treat it. Read now
Mitochondrial uncoupling is primarily facilitated by uncoupling proteins (UCPs) and adenine nucleotide translocase (ANT) [124, 128, 129]. Although UCP1 is primarily expressed in brown adipose, UCP2 is expressed across a wide variety of tissues, and expression of UCP3 appears to be limited to skeletal muscle and the heart . Knockout of UCP2  or UCP3 [94, 132] increases mtROS production, and both proteins are inactivated through glutathionylation by GSH , further establishing their involvement in antioxidant defense. UCP2 and UCP3 may also be activated by products of lipid peroxidation induced by mtROS . However, the potential for UCP2 and UCP3 to reduce mtROS through uncoupling is not fully agreed upon;  UCPs may alternatively protect against oxidative damage merely by exporting lipid hydroperoxides . Furthermore, UCP3 is less abundant in type I and type IIa muscle fibers , which are more oxidative, and its expression and content are further decreased by endurance exercise training [135, 136], suggesting that UCP3 may not be a primary defense against mtROS.
Weight loss is the primary reason my patients use the ketogenic diet. Previous research shows good evidence of a faster weight loss when patients go on a ketogenic or very low carbohydrate diet compared to participants on a more traditional low-fat diet, or even a Mediterranean diet. However, that difference in weight loss seems to disappear over time.
This paleo keto bread recipe makes a delicious option for coconut lovers. For a low-fuss loaf, blend coconut flour with ingredients like eggs, coconut oil, and salt — then bake away for a sturdy bread with only 1.3 net carbs per serving. Make this recipe totally nut-free (and more Bulletproof) by swapping almond milk with full-fat canned coconut milk.
β-hydroxybutyrate and, in some cases, acetoacetate contribute to protection against oxidative stress by decreasing production of mitochondrial reactive oxygen species (mtROS), by increasing expression or protein content of antioxidant enzymes through histone deacetylase (HDAC) inhibition, and by directly scavenging the hydroxyl radical (•OH). Upregulation of antioxidant enzymes through HDAC inhibition includes manganese superoxide dismutase (SOD2), catalase, and metallothionein II and is likely mediated by the transcription factor forkhead box O 3a (FOXO3a).
Thanks for replying. I guess I’ll just try it on both convection and regular and see which works out best! 🙂 I had made the sub roll in a regular oven with good results yet it didn’t turn out as well when baked on convection. That’s why I was wondering about the temperature and whether that was the culprit. Guess there’s only one way to find out. This experimenting can get expensive!
Typically jam-packed with fruit and sugar, your average smoothie bowl isn’t a keto-friendly way to start the day. This chia smoothie bowl by Fat for Weight Loss, though, uses ingredients like coconut cream, avocado, chia seeds, and desiccated coconut for healthy fats, along with blueberries, erythritol, and a little vanilla for that smoothie bowl sweetness. At six grams of net carbs per serving, this sweet, creamy breakfast bowl is a great option when you’re craving something sweet. Top with whatever seeds your heart desires, coconut, and low-sugar fruit, like strawberries.
Metabolic syndrome is quite common. Approximately 32% of the population in the U.S. has metabolic syndrome, and about 85% of those with type 2 diabetes have metabolic syndrome. Around 25% of adults in Europe and Latin America are estimated to have the condition, and rates are rising in developing East Asian countries. Within the US, Mexican Americans have the highest prevalence of metabolic syndrome. The prevalence of metabolic syndrome increases with age, and about 40% of people over 60 are affected.
Despite continuous advances in the medical world, obesity continues to remain a major worldwide health hazard with adult mortality as high as 2.8 million per year. The majority of chronic diseases like diabetes, hypertension, and heart disease are largely related to obesity which is usually a product of unhealthy lifestyle and poor dietary habits. Appropriately tailored diet regimens for weight reduction can help manage the obesity epidemic to some extent. One diet regimen that has proven to be very effective for rapid weight loss is a very-low-carbohydrate and high-fat ketogenic diet.
Hi Maria, I love your bread recipes but can’t get over the one thing, the gritty texture you get in one every couple bites due to the psyllium husk, I have tried different brands and all have it. I haven’t tried Jay Robs yet. But have you tried ground up chia seeds instead by any chance? I read somewhere to just add twice the amount of water. Thanks
^ Lockyer, Christina (1991). "Body composition of the sperm whale, Physeter cation, with special reference to the possible functions of fat depots" (PDF). Journal of the Marine Research Institute. 12 (2). ISSN 0484-9019. Retrieved 2014-04-25. The significant levels of carbohydrate, probably mostly in the form of glycogen, in both blubber and muscle, may represent an instant form of energy for diving via anaerobic glycolysis.
How long does it take to get into ketosis? This will depend on a few factors, including how strictly you limit your carb intake and also certain variables that are mostly out of your control, like your genetics, medical history, body composition and energy needs. If you’re consistently eating from food list, you should be able to see results and improvements within a short couple of weeks.
My name is Ruben Katherine.The conclusion by medical doctors that HIV has no cure is certainly not true because I’m a leaving testimony of how Dr MAGGI uses black seed extracts and other herbal materials to cure HIV/AIDS and HERPES virus. I was leaving with HIV for more than 8years, consulted many doctors for treatment but all they administer is antiretroviral drugs which depresses me even more. On this blessed day i went to the river side to reflect and maybe commit suicide due to HIV. While there a lady Maria noticed i was deep in thoughts and ask me what the trouble is and i told her my pains she offered to help because she has also benefited from Dr. MAGGI cure. Right there she sent a mail to an African based herbalist (Dr MAGGI) who replied and requested i send him information about myself. This conversation changed my story for good because less than 3weeks of using his herbal remedies which he sent to me through courier Service the virus was completely out of my body and this shocked my personal home doctors. One would have thought the solution to this demon called (HIV), Herpes, Cancer or HPV etc would come from the world recognized scientists. Hey, if you are tired of antiretroviral drugs, heartbroken and in need of solution contact him on: (Maggiherbalcenter@gmail.com) or watsapp +2348148487280.
If you do not have an Instant Pot yet, I have to tell you, I am not a gadget girl and I adore my slow cooker. I like the idea of filling my slow cooker the night before, place the shell in the fridge overnight and turning it on in the morning and allow the meal to cook while I am working or exploring nature all day. However, the Instant Pot was easy to fall in love with. It is also a slow cooker! And on days when I forget to plan ahead, I can make a delicious meal in minutes. Click HERE to find the Instant Pot I love.
For those, like myself, wanting a low-carb real bread I would recommend a proper low-carb yeast bread recipe with vital wheat gluten (the vast majority of people have zero gluten sensitivity, so the gluten-free fad is at best a waste and at worst a scam). Such breads have approx 1.5-2 grams more net carbs per 40g slice (5-6 grams total net carbs) than this recipe and I think it’s worth it.
While tender, chocolatey donuts are perfect on their own, this keto breakfast recipe amps them up with a rich and sweet glaze. Pair with coffee and tea, or enjoy as dessert (if you can wait that long). At just over 2 net carbs per donut, they’re basically guilt-free. For more Bulletproof donuts, use grass-fed butter and mold-free coffee, plus full-fat coconut milk instead of heavy cream in the glaze.
Low blood sugars can be caused by not eating enough, or by trying to lower your sugar too quickly. A blood sugar under 60 is considered dangerous. It can lead to confusion or loss of consciousness, which can be deadly. It is important to have a snack with you at all times in case this happens to you. If it does happen, think about what you did or didn’t do that lead to the low number. If it happens often, start writing things down to help you track what the cause is so that you can avoid it.
I am very happy today to share this amazing testimony on how Dr. MAGGI the herbal doctor was able to cure me from my HIV Virus with his herbal medicine. I have been a HIV patient for almost 8 months now and have tried different methods of treatment to ensure that I am cured of this terrible disease, but none worked for me, so I had to leave everything to God to handle as I was a Christian who had faith that one day God would intervene in my life, yet I felt so sad and desperate as I was losing almost everything due to my illness, A few months ago while I was surfing the internet I saw different recommendation about Dr MAGGI on how he have been using his herbal Medicine to treat and cure people, these people advice we contact Dr. MAGGI for any problem that would help immediately, I contacted Dr MAGGI and I told him how I got his contact and also about my disease, after some time Dr.MAGGI told me to have faith that he would prepare medicine for me a medication of herbal herbs, he told me I would take this medicine for a few weeks and also asked for my home address so as possible for him to submit the drug for me, so my good friends after all the process and everything Dr MAGGI actually sent me the medicine, I took it as I was directed by Dr. MAGGI, after a few weeks passed, while on Dr.MAGGI medication I began to experience changes in my body, I had to call my doctor at the hospital for some blood test after test my hospital doctor told me that I was no longer with the Hiv virus and my blood is pretty good, I can’t even believe this, Friends well today i am Hiv Negative and i want everyone to know that there is a cure for Hiv for those who will contact Dr MAGGI after reading my testimony, you can kindly contact Dr. MAGGI on Email:Maggiherbalcenter@gmail.com or call +1(305)697-6952 OR whatsap him +1(306)993-9253,or you can also check him on his Wixsite: https:maggiherbalcenter.wixsite.com/drmaggi
Weighed my ingredients…used Jay Robb Psyllium ground down to half the amount exactly…used almond flour from nuts.com….used All Whites 100% Egg Whites. Bread fell about one minute after I took it out of the oven. Do you cool yours out of the pan or in it? Does that matter? Could that be the problem? Or could it be my vinegar? Have had it a few months…does it get old? Help!!! I promised my husband if he let me spend all this $ on ingredients I could give him a nice loaf of bread for sandwiches! So disappointed! But determined!
Can you put any yeast in the mixture? And if you did, would it help it rise more in addition to tasing more “yeasty”? I have been making (with great results) a browner, wheat colored bread from a recipe called Diedre’s For Real Low Carb Bread. It uses yeast and only has one rise after kneading with my dough hook attachment on my mixer. I would like to try some white bread.
Lower HbA1c: HbA1c is an abbreviation for ‘glycosylated hemoglobin.’ Hemoglobin is a protein inside red blood cells, this means it is always exposed to the substances that circulate in the blood (i.e glucose). When glucose levels are high, glucose can bind to hemoglobin (i.e it becomes glycoyslated). As red blood cells survive inside the body for 100-120 days, the amount of glyosylated hemoglobin is a good indicator of long term glucose control. The healthy limit for HbA1C is below 5.7% (Source: WebMD).
God bless Dr. Ariba for his marvelous work in my life, I was diagnosed of HERPES since 2016 and I was taking my medications, I wasn’t satisfied, i needed to get the HERPES out of my system, I was directed by my brother in-law to meet Dr Ariba. who is good at curing HERPES, DIABETES,HIV/AID and CANCER with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine through UPS delivery service (UPS). I took the medicine as prescribed by him and 13 days later i was cured from HERPES, Dr.Ariba truly you are great, do you need his help also? Why don’t you contact him through email: email@example.com Or contact him on whatapp via +2348138140874
Fantastic! So easy to make. Not sure if I didn’t mix mine well enough, but it had a couple of “air holes” in it after baking. Did not matter…tastes great. I made a grilled cheese out of two of the slices…delicious! I can’t wait to try some of the ideas from the comments: adding herbs and/or spices, adding cinnamon and stevia, etc. Seems the possibilities are endless.
I’m just starting a new low carb diet and I love your channel. You have so many great and easy recipes but I will definitely be trying this bread out. I love burgers, and was sad I won’t be able to have a bun anymore. I tried a different recipe before and it just tasted like eggs. This looks like it will work much better for me. I may try and make a few batches all at once in the oven and then freeze it for later. Rock on! \m/
Who would have ever believe that herbs can cure four years HERPES in my body, i never believe that this will work i have spend a lot when getting drugs from the hospital to keep me healthy, what i was waiting for is death because i never believed that i will ever get cured,but this faithful day y friend who was also HERPES positive to the Dr, after i came across a testimony on the internet of a lady on a forum who said she live in Florida testifying about a man called Dr Oniha who cured her from HERPES SIMPLEX VIRUS, i decided to email him, unknowingly to me that this will be the end of the HERPES in my body, he prepare the herb for me, and give me instruction on how to take it and after that, he told me to go to the hospital for a check up, and i did exactly what he instructed, surprisingly after the test the doctor confirm me negative, i thought it was a joke, i went to other hospital to do another test and it was also negative, then i took m the treatment she was also confirm negative . He also have the herb to cure cancer please i want every one with this virus to be free, that is why am dropping his email address, onihaspelltemple @gmail.com and his contact number +1(669)221-3962. thank you once again Dr Oniha for saving my life, and I promise I will always testify for your good work….
Hello!! Went grain free about two months ago to reverse a chronic illness. Am feeling great but was jonesing for a piece of bread!! Big time!! And that’s what you gave me! I wish I could share the photos I have of this loaf which baked up beautifully!! It is light and airy and tastes mild and yummy. Interestingly, when I toasted it up, a hint of coconut came out (obviously from the coconut flour). Thank you so much for sharing this… sandwich here I come!!
In the United States, metabolic syndrome has a high prevalence in African Americans, particularly African American women, and this has been attributed to the higher prevalence of obesity, hypertension, and diabetes in this population.  However, the highest age-adjusted prevalence of metabolic syndrome in the United States is found in Mexican Americans, approximately 31.9% of whom had the condition (compared with 27% of the general population) in a 1988-1994 survey. 
Although convincing, the bulk of evidence in relation to the inhibitory effects of ketosis on appetite is still anecdotal. Preliminary scientific reports seem to support this phenomenon, and the evidence shows that KD is more effective, at least in the short/medium-term, on fat loss (Paoli, 2014). It was demonstrated that diet-induced weight loss leads to changes in energy expenditure and in appetite-regulating hormones that facilitate weight regain and the return to initial energy homeostasis (Sumithran et al., 2011). This response to alteration of energy balance nullifies the success of many dietary approaches. It is well-known that the long-term success of a nutritional approach is defined by the amount of weight regain and is the main problem regarding the so-called weight cycling or “yo-yo” effect (Jeffery, 1996). A recent study by our group has demonstrated that a brief ketogenic period, if followed by a longer period of correct Mediterranean diet could avoid this yo-yo effect (Paoli et al., 2013). During the ketogenic period subjects reported less hunger, confirming previous studies (Nickols-Richardson et al., 2005; Johnston et al., 2006; Johnstone et al., 2008) on hunger-suppression effect of ketogenic diet. Despite these clinical findings, the mechanisms of action of ketosis on appetite reduction are still not completely understood. Clinical results are suggestive of both direct and indirect (via modifications of hunger-related hormones concentration) actions of KBs on appetite (Sumithran et al., 2013).
PLEASE READ HERPES CURE. HI Everyone, I’m from Florida USA. I would like to share my Testimonies with the Public about how this great Man named Dr. Mohammed heals my Herpes. I was a HERPES patient for over a YEARS AND TWO MONTHS and I was in Pain until I came across this Lady when I travelled to Holland for an Interview that happened to be a herpes patient once, I explained everything to her and she told me That there are these. Great DOCTOR to help her heal her Herpes and she gave me his email address for me to make Contact and I did as instructed. And the Dr. told me how much to buy the Herpes Herbal Drugs and how I’m going to get them, what I did. And he sends me herbal Medicine through UPS COURIER nous ICE and I use it after his Instruction And to my biggest surprise that I took the herpes HERBAL medicine for just 2 Weeks and behold, I went for a herpes test, because to my biggest Surprise for the Doctor confir Me to herpes free and said that I no longer have Herpes in my System and so far I have never felt Pain or herpes symptoms, so I said I must testify to this Man’s Kindness to the general Public, because if You surf there from this herpes problem or any Fatal Illness or other Illnesses, because I will advise you to contact him on his Work Mail:
Keeping a log of your blood sugars is a great way to be knowledgeable about your body and how it is reacting to foods and events. To start, check before and after every meal, along with one in-between meal check. It is important that you keep a log of these blood sugars, along with all of the foods that you are eating, activities you are performing and any insulin or medications that you are taking. Do this for a week, and see if you can identify any patterns. Take this log to your doctor and talk to them about your findings.
When you are separating the eggs if you use the method of pouring the egg from one half of the shell to the other you have to be extremely careful because the sharp shell can easily break the yolk. There are tools that you can purchase that will cradle the yolk and let the white run into a separate bowl. Or, you can use your hands. You need to make sure that your hands are extremely clean and fresh from being washed. Break the egg into one hand and let the white slip between your slightly separate fingers. The yolk will settle into your hand and the white will slip off into the bowl.
Make this keto bread pizza base crispy and thin, or roll it into a thicker, fluffier crust — no matter how you prepare it, this recipe cuts out all dairy, grains, and gluten for a total of 6 net carbs. Coconut flour and psyllium creates a firm texture, while apple cider vinegar lends a tangy flavor. To stay more Bulletproof, avoid eating garlic and psyllium husk too often.