The liver is the largest solid organ in the body; and is also considered a gland because among its many functions, it makes and secretes bile. The liver is located in the upper right portion of the abdomen protected by the rib cage. It has two main lobes that are made up of tiny lobules. The liver cells have two different sources of blood supply. The hepatic artery supplies oxygen rich blood that is pumped from the heart, while the portal vein supplies nutrients from the intestine and the spleen.
If you are one of those people carrying around extra weight, get started losing weight now. It doesn’t take much weight loss to improve your liver health. There are many approaches to losing weight, which you should discuss with your healthcare provider. And don’t forget to combine your weight loss program with exercise, which has also been shown to improve liver health. I’ll see you at the salad bar.
Eliminate soda from your diet. These sugary beverages keep your sweet tooth alive, and it is possible to consume much soda in a short amount of time. If you are a soda drinker, cutting out these beverages will make a big change in your sugar consumption. Good substitutions include flavored sparkling water or seltzer water with lemon or lime. A report in the August 2013 issue of "Obesity Reviews" states that reducing your intake of sugar-sweetened beverages will reduce your risk of obesity and obesity-related diseases, such as type 2 diabetes.

Measuring blood ketones is the most reliable method. There is a home blood test you can use, but the strips can be very expensive. An alternative is to measure ketones in the urine with a dipstick test, which is much more accessible and inexpensive. However, this method is much less reliable and as time goes on and the body adapts to ketosis, it becomes even less reliable.
This is why you might realize you’ve put on weight even though your habits haven’t changed, or even if you’ve gotten healthier as you’ve gotten older. “Every few decades, women should be eating less than they did before,” says Bhatia. Specifically, the USDA recommends women aged 19 to 30 eat no more than 2,000 calories a day, but the number drops to 1,800 for women aged 31 to 50, then it shifts yet again to 1,600 for women 51 and over. So yes, the older you are, the more you may have to alter your lifestyle to account for your metabolism. The good news is that when you’re eating a lot of fresh, wholesome foods, you should still be able to stick within those calorie bounds and feel satiated.

Ketones produced by the body are often associated with following a low-carbohydrate diet, according to the Better Health Channel. This is because the body breaks down sugars stored in the muscles when you do not eat enough carbohydrates. While dieting in general results in the release of some ketones, those following low-carbohydrate diets are likely to release a higher number of ketones.
I've been on keto for a few months, and as I've read about exogenous ketones it seems like there really isnt a consensus on whether they actually do much. From personal experience, I've been kicked out of ketosis twice since I started due to eating some holiday sweets. Both times I did daily tests with ketostix, one without this supplement, one with, and it took me the same amount of time to get back into ketosis.
The next thought was that lowering dietary fat, especially saturated fats, may help lower cholesterol. While untrue, there are still many who believe it. In the 1960’s the Framingham Diet Study was set up to specifically look for a connection between dietary fat and cholesterol. This was the same Framingham as the famous Heart Studies, but references to the Framingham Diet study are virtually non-existent. Why haven’t you heard of it, before? Well, the findings of this study showed no correlation between dietary fat and cholesterol whatsoever. Because these results clashed with the prevailing ‘wisdom’ of the time, they were suppressed and never published in a journal. Results were tabulated and put away in a dusty corner. Dr. Michael Eades was able to track down a copy of this forgotten gem and wrote about it’s eerily prescient findings here.

Blood samples for measurement of liver enzymes, cholesterol, triglycerides, glucose, and insulin were obtained after an overnight fast at months 0, 3, and 15. Routine biochemical tests were performed using a Hitachi 747-100 analyser (Roche, Australia). Circulating insulin was determined using the Tosoh AIA600 analyser two site immunoenzymometric assay (Tosoh Medics, San Francisco, California, USA) with a coefficient of variation of 4–5%. Insulin resistance was determined using the homeostasis model of assessment (HOMA)19 with an upper threshold of 1.64.20
Some studies have shown as few as 3% of people with NASH developing cirrhosis, while others have shown as many as 26% doing so. There's no test or risk factor that predicts who will develop cirrhosis and who won't, although one study did find that people who are older or whose initial liver biopsies showed more inflammation were at greater risk. It's clear, though, that the prognosis for NASH is far better than it is for steatohepatitis that's the result of heavy alcohol consumption. Perhaps as many as half of all those with alcoholic steatohepatitis (which lacks a handy acronym) go on to develop cirrhosis.
Yes, you can actually boost your metabolism, but—no surprise here—there is no silver bullet. Despite what Instagram influencers or clever advertisements will lead you to believe, the methods of boosting your metabolism are the same habits of a healthy and active lifestyle: strength training, eating well with a focus on high-quality foods, sleeping enough, and staying hydrated. Do these things, and you’ll not only stoke your metabolism, but you’ll also run stronger and avoid injury.
Dr Davis, I want to do everything in my power to stop this from happening to him again and to take proactive measures so it wont happen to me in the future. (Hence why I commenced your diet) . However I recently had a Cholesterol blood test done and I was shocked to see that my results appear worse after the Wheat Belly Diet than before the diet. My doctor said my total cholesterol is a bit HIGH. (5.6 mmol /L) ???
Symptoms of cirrhosis of the liver include easy bruising may occur due to decreased production of clotting factors; bile salts can deposit in the skin causing itching; gynecomastia or enlarged breasts in men may occur because of an imbalance in sex hormones; specifically an increase in estradiol; impotence (erectile dysfunction, ED), poor sex drive and shrinking testicles are due to decrease in function of sex hormones; confusion and lethargy may occur if ammonia levels rise in the blood stream (ammonia is a waste product formed from protein metabolism and requires normal liver cells to remove it), ascites (fluid accumulation within the abdominal cavity) occurs because of decreased protein production; and muscle wasting may occur because of reduced protein production. Additionally, there is increased pressure within the cirrhotic liver affecting blood flow through the liver. Increased pressure in the portal vein causes blood flow to the liver to slow down and blood vessels to swell. Swollen veins (varices) form around the stomach and esophagus and are at risk for bleeding.
Whether you're whipping up cookies or oatmeal, sprinkling some cinnamon on sugar-laden foods can help keep food comas and subsequent snacking at bay, says Mass. What’s more, a study published in the Journal of Medicinal Food concluded that eating cinnamon on any type of food, including sugary ones, helps lower the amount of sugar in your blood after you haven't eaten in a while. And that can help you lose weight because because you'll fend off insulin resistance, which can make you put on extra pounds. 

The prevalence of NASH has reached epidemic proportions with as many as 25 million U.S. adults having the disease, as reported in a Newsweek article entitled “NASH is the 21st century’s looming public health threat.” The article accurately reflects the critical aspects of this disease, specifically in its early stages with mild fibrosis, the disease can be improved with lifestyle changes including weight loss. However, when fibrosis is advanced, and particularly when cirrhosis is present, weight loss has much less effect and the only resort may be a liver transplant.

Get moving. Research shows that people who are able to keep weight off long-term exercise close to an hour every day. The National Weight Control Registry, a database that follows people who successfully lose weight and keep it off, reports that 90 percent of their members exercise for an average of one hour per day. Studies also show that people who burn a lot of calories through daily exercise but eat enough to maintain their weight can raise their metabolic rate. Roberts adds, "Exercise has a transient effect. For a while after you exercise, your metabolism is increased. And then, long-term, the increase in muscle mass you get from weights has a small effect."


Why is the keto diet good for you? A keto diet is one that prioritizes fats and proteins over carbohydrates. It can help reduce body weight, acne, and the risk of cancer. Find out about the mechanisms through which it achieves these benefits and the research that supports it. This MNT Knowledge Center article also discusses the risks of the diet. Read now
Catherine Saxelby knows nutrition! She is an accredited nutritionist, food commentator, blogger and award-winning author. Her latest book Catherine Saxelby's Food and Nutrition Companion answers all those tricky questions on healthy eating, diets and supplements. It draws together a lifetime of advice and gives you all you need to know to eat right! It's a complete A to Z. A handy desk go-to reference.
The reduction in the ratio of apoB-100 to apoA-I could translate into a significant decrease in risk of cardiovascular disease in metabolic syndrome (2). Although we may have seen an increase in HDL concentration with a longer period of weight maintenance, our data suggest that achieving a similar effect in the short-term would require other treatments, such as peroxisome proliferator–activated receptor-α agonists (3) that increase apoA-I secretion. Rimonabant also incrementally increases HDL relative to weight loss and may partly achieve this by increasing plasma adiponectin.
To lose fat, you need a calorie deficit, where you're consuming fewer calories than you're burning. A calorie deficit of 3,500 will lead to 1 pound of fat loss. Therefore, the amount of fat you can lose by cutting out sugar and starches depends on how much of them you're eating. If you're currently consuming 500 calories per day from starch and sugar, cutting them out would equal 3,500 calories fewer every week, which would lead to 1 pound of fat loss.

A few years ago, for example, a 55-year-old woman arrived at the Pritikin Longevity Center weighing 218 pounds. Her resting metabolic rate was tested. (Resting metabolic rate, or RMR, is the number of calories your body just naturally burns each day, without exercise.) This woman’s was 1440. Four years later, eating and exercising Pritikin-style, she returned to Pritikin. The scale had fallen to 198, her body composition (ratio of muscle to fat) had significantly improved, and her RMR had risen to 1640.


Hipskind, P., Glass, C., Charlton, D., Nowak, D., & Dasarathy, S. (2011). Do Hand-held Calorimeters Have a Role in Assessment of Nutrition Needs in Hospitalized Patients? A Systematic Review of Literature. Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, 26(4), 426–433. doi: 10.1177/0884533611411272
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Obese individuals who walked on a treadmill7 for one hour per day improved insulin resistance, boosted adiponectin levels, lowered free radical damage, and improved fatty liver problems. Another study showed that placing sedentary obese adults on a four week aerobic cycling8 and stretching program cleared out 21 percent of their liver fat, clearly helping to unclog their livers.

 The Weight Loss/ Metabolism Correction is 12 weeks of medical treatment. It costs $1,200. The clinic accepts health savings account (HSA), flexible spending account (FSA), as well as Care Credit (6-month interest free financing; electronic application is available in the clinic). The clinic will submit a letter documenting medical necessity to insurance companies at the request of the patient. 
That was the bad news. But the good news is that it’s obviously still possible to lose weight anyway; after all, plenty of people do. Understanding the hormonal adaptations that make weight loss harder can help you make a plan for combating them, and at the very least the knowledge can help you be compassionate to your body: it’s only trying to keep you alive!

A 2001 study published in International Journal of Obesity followed overweight subjects whose diets derived either 10 or 5 percent of calories from sucrose.[4] On a 2,000-calorie diet, this would be the difference between 50 and 25 grams of sugar per day. After eight weeks, there were no significant differences in weight loss or BMI. In fact, the high-sugar group lost about 1-1/2 pounds more, but this effect was statistically insignificant.
Some people can work their way up to a whole lemon a day, but that takes time. This may initially act as a diuretic because it stimulates the toxins in your liver to be released from your body. If this becomes uncomfortable or if you experience a headache (also due to toxins being dislodged from your liver and released into your bloodstream), reduce the amount of lemon you are using. Over time, as your liver becomes used to this cleanse, you will be able to use more lemon and cleanse more thoroughly.
It's also important that people with fatty liver disease avoid excessive alcohol and unnecessary use of medications, which can put stress on the liver. Carefully follow medication instructions and warnings. For instance, acetaminophen — a pain reliever found in many prescription and nonprescription drugs — can cause liver damage if more than the recommended amount is taken. The risk of liver injury primarily occurs when people exceed the current maximum dose of 4,000 mg within a 24-hour period.
“If you’re going to use lifestyle to lower your cholesterol, you have to do it regularly. You can’t just do it for a few months and then quit,” says Dr. Goldberg. She also points out: “Some people are genetically programmed to make more cholesterol than others. The diet and exercise may not be enough for these people based on the level of their cholesterol and global risk for heart disease.”
Here’s the bottom line: There are a lot of companies that claim to have the new magic pill. Weight-loss supplements are popular because they don’t require work. The truth is there is no magic pill. To lose weight and stay healthy, it’s best to eat a well-rounded diet, and you can rely on fat-burning foods that have been consumed by humans for thousands of years.
Over five visits, participants (n = 16) consumed either 4.4 mmol.kg−1 of βHB (2.2 mmol.kg−1 or 395 mg/kg of KE; 1 mole of KE delivered 2 moles of d-βHB equivalents): twice whilst fasted, and twice following a standardized meal, or an isocaloric dextrose drink without a meal. To improve palatability, drinks were diluted to 500 ml with a commercially available, citrus flavored drink containing 65 kCal (5 g of carbohydrate) (Glaceau, UK). The dextrose drink was taste-matched using a bitterness additive (Symrise, Holzminden, Germany). The standard meal consisted of porridge oats (54 g), semi-skimmed milk (360 ml) and banana (120 g), giving 600 kCal per person, with a macronutrient ratio of Carbohydrate: Protein: Fat of 2:1:1.

My case was a quandary: I already exercised diligently, running about four miles most days. I had long ago given up red meat and most cheese. Yet my bad cholesterol last October was 169, way above my recommended high of 130 and an optimal 100. (People’s LDL goals depend on their number of risk factors such as smoking, diabetes or high blood pressure.)
“Believe in yourself and know that you can achieve your goals,” Noble says. “Know that this will take some time, but understand that it took time for you to get to your starting point. The principles outlined in this book are easily sustainable, inexpensive to follow and will provide you with basic rules that allow you to structure your life eating at home or in a restaurant if needed.”
You need some fat in your diet, but probably less than you think. Plus, the type of fat matters. Unsaturated fats -- like those found in canola, olive, and safflower oils -- lower LDL "bad" cholesterol levels and may help raise HDL "good" cholesterol. Saturated fats -- like those found in meat, full-fat dairy, butter, and palm oil -- raise LDL cholesterol. Remember, good fats have just as many calories, so use just a bit.
Hi, my name is Kate and I would like to share my story. A few years ago, my body was full of cellulite. I used to be disgusted at how much cellulite I had. But, with patience and determination (and a lot of research!), I managed to almost eliminate it. All it took, was the right exercise program and a way to manipulate estrogen metabolism. Read my story here ==>... http://bit.ly/cellulitecured
HRQL was measured at months 0, 3, and 15 using the short form 36 (SF-36) questionnaire.22 The SF-36 questionnaire measured eight multi-item scales called health domains (physical functioning, physical role limitation, bodily pain, general health, vitality, social functioning, emotional role limitation, and mental health). Scores were assembled and transformed using previously described methods.22 Higher transformed scores indicated better health. Two summary scores, the mental component score (MCS) and the physical component score (PCS), were calculated via a weighted combination of the eight health domains. SF-36 scores obtained from patients with chronic liver disease were compared with Australian population norms.23

Hipskind, P., Glass, C., Charlton, D., Nowak, D., & Dasarathy, S. (2011). Do Hand-held Calorimeters Have a Role in Assessment of Nutrition Needs in Hospitalized Patients? A Systematic Review of Literature. Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, 26(4), 426–433. doi: 10.1177/0884533611411272

One type of sugar isn't necessarily better than another, but there's definitely a difference in the foods containing natural or added sugars, says Fear. Case in point: A sugary banana comes with a lot more good-for-you nutrients—and less calories, saturated fat, and trans fat—than a glazed donut. And guess what? One banana actually packs more grams of sugar than that donut. Go figure. What’s more, foods that contain natural sugars usually have other nutrients, such as fiber (as is true with bananas), protein, and healthy fats, she says. Keep reading to find out why this is so important—and instead of focusing on the sugar content of those sweet foods, think about the food’s overall nutritional value, says Fear.
Methods and Results: In the first study, 15 participants consumed KE or KS drinks that delivered ~12 or ~24 g of βHB. Both drinks elevated blood D-βHB concentrations (D-βHB Cmax: KE 2.8 mM, KS 1.0 mM, P < 0.001), which returned to baseline within 3–4 h. KS drinks were found to contain 50% of the L-βHB isoform, which remained elevated in blood for over 8 h, but was not detectable after 24 h. Urinary excretion of both D-βHB and L-βHB was <1.5% of the total βHB ingested and was in proportion to the blood AUC. D-βHB, but not L-βHB, was slowly converted to breath acetone. The KE drink decreased blood pH by 0.10 and the KS drink increased urinary pH from 5.7 to 8.5. In the second study, the effect of a meal before a KE drink on blood D-βHB concentrations was determined in 16 participants. Food lowered blood D-βHB Cmax by 33% (Fed 2.2 mM, Fasted 3.3 mM, P < 0.001), but did not alter acetoacetate or breath acetone concentrations. All ketone drinks lowered blood glucose, free fatty acid and triglyceride concentrations, and had similar effects on blood electrolytes, which remained normal. In the final study, participants were given KE over 9 h as three drinks (n = 12) or a continuous nasogastric infusion (n = 4) to maintain blood D-βHB concentrations greater than 1 mM. Both drinks and infusions gave identical D-βHB AUC of 1.3–1.4 moles.min.
Summer is upon us and this often causes stress for many people battling weight issues. One of the most overlooked underlying causes of weight loss resistance is a liver that is over burdened with toxins. Bringing health and balance back to the liver is often the missing key to sustained weight loss. Read on to find out how the liver causes unwanted weight gain, how to know if your liver is toxic and what to do about it! 
“You can do that by making sure that the mass majority of your food choices are fiber-rich, water-rich foods. It’s foods like whole fruits, vegetables, and cooked whole grains like quinoa, farro, oatmeal and 100% whole-wheat pasta. It’s legumes like beans, lentils and peas. It’s starchy veggies like potatoes and yams,” advises Dr. Tom Rifai, MD, FACP, Regional Medical Director of Metabolic Health & Weight Management at Henry Ford Health System in Michigan, and member of the Pritikin Scientific Advisory Board.
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