HDL cholesterol has long been considered “good” because it is largely responsible for picking up excess cholesterol from tissues, including the artery wall, and bringing it back to the liver for disposal. This process is known as reverse cholesterol transport. It’s easy to remember if you think of HDL as the garbage trucks that help rid the body of garbage (LDL).
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These two meta-analyses (and the other research you’ll find in this article on keto & weight loss) provide us with a look at the real world significance of low-fat and low-carb diets. When you put people on a low-carb ketogenic type diet, they tend to lose more weight than people who are on a low-fat diet. The ketogenic diet also provides us with clear rules to follow, which makes it is easier for us to keep ourselves from overeating.
According to some studies, medium-chain fats offer better protection from infections than longer-chain fatty acids do. A study published in the Journal of Nutritional Biochemistry found that fatty acids and monoglycerides with chain lengths varying from 8–12 carbons were found to be more strongly antiviral and antibacterial when added to milk and formula than long-chain monoglycerides. Medium-chain lipids added to milk (lipid-enhanced milk) and formula inactivated a number of pathogens, including respiratory syncytial virus (RSV), herpes simplex virus type 1 (HSV-1), haemophilus influenzae and streptococcus. (10)
Just remember that all olive oil is not created equally. Unfortunately, most commercial manufacturers that are trying to ride the health hype on olive oil have rushed to the market with all kinds of fake olive oils, which are imitations and inferior products. The problem is these oils aren’t always harvested or processed properly, which can kill many of their delicate nutrients and turn some of their fatty acids rancid or toxic.
The premise of the ketogenic diet for weight loss is that if you deprive the body of glucose—the main source of energy for all cells in the body, which is obtained by eating carbohydrate foods—an alternative fuel called ketones is produced from stored fat (thus, the term “keto”-genic). The brain demands the most glucose in a steady supply, about 120 grams daily, because it cannot store glucose. During fasting, or when very little carbohydrate is eaten, the body first pulls stored glucose from the liver and temporarily breaks down muscle to release glucose. If this continues for 3-4 days and stored glucose is fully depleted, blood levels of a hormone called insulin decrease, and the body begins to use fat as its primary fuel. The liver produces ketone bodies from fat, which can be used in the absence of glucose. 
Complex high fat foods such as extra virgin olive oil, when eaten with a wide variety of other healthy polyphenol-dense foods, provide the basis for a rich and diverse community of gut microbes. This diversity is increasingly being shown to be important for our health. The original PREDIMED study didn’t measure gut microbes directly (although subsequent research is doing so) but the striking benefits of the Mediterranean diet and particularly extra virgin olive oil are that they are superb gut microbe fertilisers and improve gut health.
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And monounsaturated fat isn't the only thing olive oil has going for it nutritionally. Some olive oils come with phytonutrients that may offer their own disease protection benefits (still, it's not clear whether most of us can take in enough of these phytonutrients without going overboard on olive oil, says Joyce Nettleton, DSc, RD, researcher and editor of the PUFA Newsletter).